Leaky Gut and Autoimmune Disease: Making Sense of the Connection


I want to explain to you the root cause of autoimmune disease. Hang in there through the science language – it’s worth it. You will never look at autoimmune disease the same way again.

Some say which autoimmune disease you have is not important – what is important is resolving the underlying intestinal permeability so the autoimmune disease doesn’t move throughout the body. Altered mucosal integrity of the intestine, also known as increased intestinal permeability, also known as leaky gut, is associated with some autoimmune conditions like Hashimoto’s Thyroiditis, Crohn’s Disease, and Psoriasis.

Intestinal permeability is altered by a variety of mechanisms, including food sensitivities and intolerances, stress, infection, impaired digestion, nutritional insufficiencies, and medications. Intestinal permeability is essentially the loosening of the bonds between cells in the intestines so that instead of those cells forming a wall, essentially unrecognizable substances can pass through the cells to the bloodstream. The result of altered intestinal permeability is an increase in food sensitivities and intolerances, malnutrition, and increased absorption of toxins and lipopolysaccharides.

An increase in the absorption of toxins results in an elevated toxic and antigenic burden on the body. This increased body burden triggers immune activation. The net result of immune activation is systemic disease. The autoimmune disease can manifest in the thyroid, the small intestine, or the skin – but the root cause is the same, and is likely to be increased intestinal permeability, or leaky gut.

This is for the visual learners out there:

Trigger   ——–>   Intestinal permeability   ——————>   Autoimmune disease

Got questions? Find it helpful? Let me know!


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